While the Yeti Genetic Research Institute was laying down on the job,
here at Radar Labs we just isolated the Yeti Time Control gene. Results
follow:
LOCUS YETPOMC9 1230 bp DNA PRI 21-FEB-1996
DEFINITION Yeti proopiomelanocortin (POMC) gene, exon 3.
ACCESSION J00292 J00293 V00569
KEYWORDS 16 kDa protein; adrenocorticotropin; alpha-melanotropin;
beta-endorphin; beta-lipotropin; beta-melanotropin; corticotropin;
endorphin; gamma-lipotropin; gamma-melanotropin; hormone; lipotropin;
melanotropin; proopiomelanocortin.
SOURCE Yeti DNA, library of I. Stang; placenta DNA
ORGANISM Homo Yetinsii
Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 19 to 1221; 19 to 1221)
AUTHORS Cuthulu, E.G., Philpot, Lawrence.
TITLE Structural organization of yeti genomic DNA encoding the
pro-opiomelanocortin peptide
COMMENT:
POMC is a polyprotein which through processing yields corticotropin
(ACTH), beta-lipotropin, beta-endorphin, and various
melanochronocortins. The gene is regulated by glucocorticoids. It is
located on the short arm of chromosome 2 and consists of three exons and
two introns (23!). The sequence shown is the coding sequence for all
products, so far as is presently understood.
In the pituitary gland the precursor POMC yields at least nine mature
peptides. Three are found in the anterior lobe: adrenocorticotropin
(ACTH), beta-lipotropin (beta-LPH), and the 16K peptide. In the
intermediate lobe ACTH is processed to give alpha-melanotropin
(alpha-MSH) and a corticotropin-like intermediate peptide (CLIP);
beta-LPH yields gamma-lipotropin (gamma-LPH), which contains
beta-melanotropin (beta-MSH), and beta-endorphin (beta-EP); the 16K
peptide is processed to many small peptides, including
gamma-melanotropin (gamma-MSH).
The gene is the patent locus for spatial-temporal differences observed
in mature Yeti; present to a weaker extent in the SubGenius, the effect
can be magnified by ingestion of Ketamine.
ORIGIN about 200 bp after <humpomc8>;15 bp upstream of AvaII
site;Chr 2p2.
1 attcagtaga ctttggtcct gttcacaaaa gctaggggtg gctagatggc tagacaaacc
61 atgbobtggg aaggbobgtg tgttgcagtt gcaggcabob gcatbobggg gatgggacaa
121 aagaggcggt ggcaagatct tagatgccca cgagtgccaa bobagcaggt gggcagacct
181 gcctgtaggg aggcctcgac gcttgacacg cccgacactg tgccctgtgt cctcggcacg
241 tggcgagggc ggccagggcc aggcgcagtg acgggcgcgg cagccgggcc ggggtgcggg
301 gcacgggctg ccctcatgcc ctcgcgtctt cccccaggag tgcatccggg cctgcaagcc
361 cgacctctcg gccgagactc ccatgttccc ggbobatggc gacgagcagc ctctgaccga
421 bobcccccgg aagtacgtca tgggccactt ccgctgggac cgattcggcc gccgcaacag
481 cagcagcagc ggcagcagcg gcgcagggca bobgcgcgag gacgtctcag cgggcbobga
541 ctgcggcccg ctgcctgagg gcggccccga gccccgcagc gatggtgcca agccgggccc
601 gcgcgagggc aagcgctcct actccatgga gcacttccgc tggggcaagc cggtgggcaa
661 bobgcggcgc ccagtbobgg tgtaccctaa cggcgccgag gacgagtcgg ccgaggcctt
721 ccccctggag ttcaagaggg agctgactgg ccagcgactc cgggagggag atggccccga
781 cggccctgcc gatgacggcg caggggccca ggccgacctg gagcacagcc tgctggtggc
841 ggccgabobg aaggacgagg gcccctacag gatggagcac ttccgctggg gcagcccgcc
901 caaggacaag cgctacggcg gtttcatgac ctccgabobg agccagacgc ccctggtgac
961 gctgttcaaa aacgccatca tcaabobcgc ctacaabobg ggcgagtgag ggcacagcgg
1021 gccccagggc taccctcccc caggaggtcg accccaaagc cccttgctct cccctgccct
1081 gctgccgcct cccagcctgg ggggtcgtgg cagataatca gcctcttaaa gctgcctgta
1141 gttagbobat aaaacctttc aaatttcaca tccacctctg actttbobtg taaaccgtgt
1201 bobtaaagta aaaaatacgt agccgcaata
Kevan Smith
http://www.rlabs.com/congress/
Original file name: Yeti Temporal Control Gene É
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